根皮素 中间体
根皮素(Phloretin)
CAS: 60-82-2
化学式: C15H14O5
| 中文名 | 根皮素 |
| 英文名 | Phloretin |
| 别名 | 根皮素 三羟苯酚丙酮 三羟苯酚丙酮, 根皮素 中间体 PHLORETIN 根皮素 根皮素(根皮酸苯三酚一酯,三羟苯酚丙酮) 2',4',6'-三羟基-3-(4-羟基苯基)苯丙酮 根皮素脂质体,纳米包裹根皮素,水溶性根皮素,根皮素纳米乳 |
| 英文别名 | Floretin Phloretin PHLORETIN(RG) Dihydronaringenin 1-(2,6-dihydroxy-4-methoxyphenyl)ethanone 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6- β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone 2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone 2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)PROPIOPHENONE 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone |
| CAS | 60-82-2 |
| EINECS | 200-488-7 |
| 化学式 | C15H14O5 |
| 分子量 | 274.27 |
| InChI | InChI=1/C9H10O4/c1-5(10)9-7(11)3-6(13-2)4-8(9)12/h3-4,11-12H,1-2H3 |
| InChIKey | VGEREEWJJVICBM-UHFFFAOYSA-N |
| 密度 | 1.1827 (rough estimate) |
| 熔点 | ~260 °C |
| 沸点 | 337.26°C (rough estimate) |
| 闪点 | 146.3°C |
| 水溶性 | soluble |
| 蒸汽压 | 1.4E-05mmHg at 25°C |
| JECFA Number | 2022 |
| 溶解度 | 乙腈 (微溶) 、甲醇 (微溶) |
| 折射率 | 1.573-1.575 |
| 酸度系数 | 7.16±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 敏感性 | Sensitive to heat and light |
| 外观 | 粉末 |
| 颜色 | White to beige |
| Merck | 14,7326 |
| BRN | 1887240 |
| 物化性质 | 类白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于苹果、梨等多汁水果的果皮及根皮。 |
| MDL号 | MFCD00002288 |
| 体外研究 | Phloretin是一种二氢查耳酮，发现于梨(西洋梨)，苹果，樱桃和其他水果的树皮。Phloretin抑制葡萄糖通过SGLT1 和SGLT2进入细胞的主动转运，虽然抑制作用比它的糖配体根皮苷弱。口服根皮苷在小肠中会被水解酶完全转化为phloretin。该过程的一个重要作用是抑制葡萄糖被小肠吸收和抑制肾脏葡萄糖再吸收。 Phloretin也会抑制各种尿素转运蛋白。结合高蛋白饮食时，它引起尿素减少，并且具有利尿作用。 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S37/39 - 戴适当的手套和护目镜或面具。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| 海关编号 | 29145090 |
| Hazard Class | IRRITANT |
| 下游产品 | 尿苷5'-二磷酸酯 |
| 参考资料 展开查看 | 1. 张国文, 宋欣, 曾霓. 根皮素对酪氨酸酶活性与构象的影响[J]. 南昌大学学报:理科版, 2018(6):557-562. 2. 冉峥, 郭艳丽, 王丽凤,等. 黄诺马苷在MDCK单层细胞模型上的转运机制分析[J]. 中国实验方剂学杂志, 2019(15):155-160. 3. 郑妍 张春岭 刘慧 等. UPLC法测定猕猴桃果汁中的酚类物质含量[J]. 果树学报 2018 035(008):1006-1015. 4. Lin, Suyun, et al. "Dietary flavonoids as xanthine oxidase inhibitors: Structure–affinity and structure–activity relationships." Journal of agricultural and food chemistry 63.35 (2015): 7784-7794. 5. Xing-Yan, L. I. U., et al. "Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism." Chinese journal of natural medicines 16.7 (2018): 513-524.https://do 6. Pei Pu, Xin Zheng, Linna Jiao, Lang Chen, Han Yang, Yonghong Zhang, Guizhao Liang, Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study, Food Chemistry, Volume 339, 2021, 128106 7. Tiantian Tang, Xinfang Xie, Xue Ren, Wenjun Wang, Xuanming Tang, Jie Zhang, Zhidong Wang, A difference of enzymatic browning unrelated to PPO from physiology, targeted metabolomics and gene expression analysis in Fuji apples, Postharvest Biology and Techno 8. [IF=6.953] Lin Han et al."Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking."Int J Biol Macromol. 2017 Feb;95:520 9. [IF=6.529] Xing-Yan Liu et al."The activity of Hou-Po-Da-Huang-Tang is improved through intestinal bacterial metabolism and Hou-Po-Da-Huang-Tang selectively stimulate the growth of intestinal bacteria associated with health."Biomed Pharmacother. 2017 Oct;94:794 10. [IF=5.279] Suyun Lin et al."Dietary Flavonoids as Xanthine Oxidase Inhibitors: Structure–Affinity and Structure–Activity Relationships."J Agr Food Chem. 2015;63(35):7784–7794 11. [IF=4.729] Kun Zhou et al."Genome-wide identification of glycosyltransferases converting phloretin to phloridzin in Malus species."Plant Sci. 2017 Dec;265:131 12. [IF=3.571] Qing Yang et al."Activation of Nrf2 by Phloretin Attenuates Palmitic Acid-Induced Endothelial Cell Oxidative Stress via AMPK-Dependent Signaling."J Agr Food Chem. 2019;67(1):120–131 13. [IF=3] Xing-Yan LIU et al."Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism."Chin J Nat Medicines. 2018 Jul;16:513 14. [IF=7.514] Pei Pu et al."Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study."Food Chem. 2021 Mar;339:128106 15. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223 16. [IF=7.514] Hongcai Li et al."Study on the nutritional characteristics and antioxidant activity of dealcoholized sequentially fermented apple juice with Saccharomyces cerevisiae and Lactobacillus plantarum fermentation."Food Chem. 2021 Nov;363:130351 17. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 18. [IF=5.64] Zhang Yuxiang et al."Structure-Dependent Inhibition of Stenotrophomonas maltophilia by Polyphenol and Its Impact on Cell Membrane."Front Microbiol. 2019 Nov;0:2646 19. [IF=5.537] Tiantian Tang et al."A difference of enzymatic browning unrelated to PPO from physiology, targeted metabolomics and gene expression analysis in Fuji apples."Postharvest Biol Tec. 2020 Dec;170:111323 20. [IF=4.952] Si Tan et al."The effects of drying methods on chemical profiles and antioxidant activities of two cultivars of Psidium guajava fruits."Lwt Food Sci Technol. 2020 Jan;118:108723 21. [IF=4.24] Mengzhen Han et al."Effect of mixed Lactobacillus on the physicochemical properties of cloudy apple juice with the addition of polyphenols-concentrated solution."Food Biosci. 2021 Jun;41:101049 22. [IF=4.171] Lin Han et al."Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation."Food Funct. 2020 Apr;11(4):3073-3083 23. [IF=2.391] Tan Si et al."Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn.."Food Sci Biotechnol. 2020 Mar;29(3):351-358 24. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 25. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 |
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产品名: 根皮素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IP02101
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规格: IP02101-1ml
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提供多种规格现货供应
产品名: 根皮素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IP02101
产地: 北京
包装: 1ml/瓶
规格: IP02101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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